Bioinformatics

Mehr zum Buch

Bioinformatics emerged to organize the vast data generated by molecular biology technologies, including large-scale DNA sequencing and gene expression profiling. This field merges traditional quantitative sciences—mathematics, statistics, computer science, and cybernetics—with biological sciences like genetics and proteomics. The textbook by Polanski and Kimmel introduces mathematical models in bioinformatics and the biological challenges that drive the development of computational tools for managing extensive data sets. The first part focuses on mathematical and computational methods, presented in a clear and descriptive manner without excessive formalism. Each of the four chapters includes exercises to reinforce understanding. The second part explores practical applications across six chapters, covering areas such as sequence alignment, molecular phylogenetics, genomics, and RNA and DNA microarrays. Each chapter ends with problems and projects, encouraging deeper exploration and method development, often using publicly available software and bioinformatics resources. The book concludes with a comprehensive bibliography, linking classic research to recent findings and offering guidance for future studies. This volume is ideal for senior undergraduates or graduate students interested in bioinformatics, emphasizing its mathematical and computational foundations.