Nongenotoxic Carcinogenesis

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The majority of human chemical carcinogens are capable of damaging DNA and are loosely defined as "genotoxic." On the other hand some chemicals which are described as non-genotoxic appear to increase the incidence of rodent cancers only as a secondary consequence of other induced toxicity. The primary action does not involve DNA damage. This book presents the concept of non-genotoxic carcinogenesis, including possible mechanisms of action. The papers presented by prominent workers provide a detailed insight into the complexity of the field.