Herbal Contraindications and Drug Interactions

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This book's first edition (1997) was pioneering in exploring herbal interactions with drugs. The 4th edition updates research findings and carefully distinguishes between knowledge gained from (1) empirical clinical observations, (2) modern clinical human studies, and (3) various laboratory research on animals and tissues. Over 2700 medical and scientific sources are cited to support these findings. It details the types of herbal preparations studied, highlighting differences in preparations from the same herb, along with dosage and duration. Conflicting results are presented to provide context. This edition emphasizes combinations of herbal preparations with drugs that enhance therapeutic effects or reduce adverse reactions, covering 98 of the 321 herbs listed. Extensive appendices categorize information on these herbs and additional remedies, addressing specific cautions, drug interactions, and precautions for mothers, infants, and children. It also includes interactions with vitamins and minerals, and beneficial combinations for treating inflammation, infections, cancer, and substance abuse. The sections on herbal influences on drug absorption and metabolism, including transport proteins, cytochrome P450 isoenzymes, and conjugating enzymes, represent the most comprehensive compilations available.