Deepak Shrivastava Bücher

Die Verwendung von Hydrotropie und gemischter Löslichkeit revolutioniert die quantitative Analyse schwer wasserlöslicher Arzneimittel, indem sie organische Lösungsmittel ersetzt. Diese umweltfreundliche Analysetechnik vermeidet die Nachteile wie hohe Kosten, Toxizität und Umweltverschmutzung, die mit herkömmlichen Lösungsmitteln verbunden sind. Durch hydrotropische Solubilisierung können präzise spektrophotometrische Schätzungen durchgeführt werden, die sicher und kostengünstig sind, ohne die schädlichen Auswirkungen organischer Lösungsmittel.

Focusing on the design and synthesis of benzimidazole derivatives, this work employs the QSAR technique to enhance antibacterial activity. Due to the lack of three-dimensional coordinates for the receptor site, an indirect drug design approach is utilized. The study aims to identify optimal chemical group distributions to achieve desired biological effects. It includes the synthesis of new derivatives and their structural confirmation, alongside a virtual screening process to evaluate their antibacterial potential.

The book delves into the advancements in medicinal chemistry, highlighting the collaborative efforts of disciplines such as organic chemistry, pharmacology, and molecular biology. It outlines the multi-stage process of developing medical agents, from chemical synthesis to clinical trials, emphasizing the importance of drug-receptor interactions. Additionally, it discusses the concept of receptor theory and the significance of isosteric replacements in creating compounds like benzoxazole, benzothiazole, and benzimidazole, showcasing the intricate nature of drug design and development.

Rapidly disintegrating dosage forms address the limitations of conventional tablets, particularly for patients needing quick relief and those with difficulties swallowing, such as the elderly, children, or individuals with limited access to water. This study focuses on the formulation of Fexofenadine HCl tablets using direct compression, incorporating various disintegrants like SSG, CCS, KCL, Xanthan Gum, and Ludiflash to enhance patient compliance and ensure effective medication delivery.

The narrative follows a resilient young girl who faces significant challenges during her childhood, including the loss of her father and the struggle for education under her mother's care. After her mother's death, she is sent to live with a cousin in America. However, her life takes a dark turn when her grandmother sells her to pimps, leading to her eventual sale to a high-class prostitute named Marten, who plans to send her to Dubai. The story explores themes of survival, betrayal, and the harsh realities faced by vulnerable individuals.

The book explores innovative drug delivery systems designed to release medication in response to the body's needs, targeting specific sites for enhanced efficacy. While no current system perfectly meets all objectives, significant progress has been made with various approaches, particularly through vesicular structures like liposomes and niosomes. These systems aim to prolong drug circulation and minimize toxicity by enabling selective uptake. The text highlights advancements in vesicular drug delivery, focusing on achieving controlled release and targeted therapies for conventional drugs.

The book explores eco-friendly analytical techniques for the quantitative analysis of poorly water-soluble drugs, emphasizing the replacement of organic solvents with methods like hydrotropy, mixed hydrotropy, and mixed solvency. It highlights the drawbacks of traditional organic solvents, such as toxicity and environmental concerns, and presents safer, cost-effective alternatives for spectrophotometric estimations. The text also suggests the use of improved hydrotropic agents to enhance analytical results, promoting a more sustainable approach in pharmaceutical analysis.

Deprescribing practice in hospice medicine has expanded exponentially in recent years. This book systematically addresses the groups of extremely useful medications to manage chronic disease conditions and prevent complications.

El libro aborda métodos analíticos ecológicos para el análisis cuantitativo de drogas poco solubles en agua, sustituyendo disolventes orgánicos por técnicas como la hidrotropía y la solvencia mixta. Se destacan métodos sencillos, económicos y seguros que evitan la toxicidad, mejorando los resultados con agentes hidrotrópicos.