Bioinformatics and Functional Genomics

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The eagerly awaited second edition of this best-selling text has been thoroughly updated and enhanced, continuing to provide a broad-based introduction to the dynamic field of bioinformatics and functional genomics. This textbook is ideal for undergraduate and graduate students, as well as those engaged in biomedical research. The initial third covers bioinformatics, focusing on the intersection of molecular biology and computing, emphasizing computer databases and algorithms for studying proteins and genes, including sequence alignment and phylogeny. The middle section delves into functional genomics, exploring techniques like gene expression profiling and proteomics to analyze cellular functions. The final third addresses genomics, examining the entire DNA collection of organisms, utilizing bioinformatics tools, and spanning the tree of life from viruses to eukaryotes, with insights into the human genome in health and disease. Key features include an attractive two-color design with full-color figures, over 500 illustrations (including 50 new ones), and a strong emphasis on how bioinformatics tools enhance our understanding of cell and molecular biology and genomics. The second edition introduces several crucial proteins to demonstrate the application of bioinformatics tools in addressing biological questions. Each chapter is equipped with a Problem Set, Pitfalls section, Boxes for key techniques and math/statistical princ