Gideon Blauer Bücher

This comprehensive work delves into various aspects of protein-ligand interactions, transport mechanisms, and the thermodynamics underlying these processes. It begins with an exploration of thermodynamics related to protein-ligand interactions and classifications of transport mechanisms through non-equilibrium thermodynamics. The investigation of membrane processes is further enhanced by chemical relaxation spectrometry and NMR studies of glycolysis in E. coli. The text then focuses on selected transport proteins, discussing serum albumin's role, intracellular binding proteins like ligandin and protein A, and the absence of heme-heme interactions in hemoglobin. It also examines multi-enzyme complexes, redox-transport modes, and energy transduction mechanisms in photophosphorylation. Subsequent sections cover proteins involved in mitochondrial calcium transport, the dynamics of proton transfer in bacteriorhodopsin, and the impact of cholesterol on mediated transport systems. The role of ion channels in excitable membranes is also highlighted. Metal transport by proteins is addressed, detailing ferritin's iron deposition, thermodynamic factors in iron binding to transferrin, and heme transport properties. A genetic defect in copper transport related to Wilson's disease is discussed. Finally, the physiological and pharmacological implications of protein transport are examined, including drug-binding properties of serum albumi

This comprehensive work covers the historical context and modern advances in porphyrins and related compounds. It begins with an overview of porphyrin biosynthesis pathways and progresses into detailed studies on metalloporphyrins, including their transient absorption spectra and excited state kinetics. The text explores various metal complexes and their optical properties, focusing on hematoporphyrin derivatives used in tumor phototherapy and the interactions of heme with globins and cytochromes. The discussion extends to bile pigments, detailing the photophysical processes of bilirubin, including its role in phototherapy for neonatal jaundice. It also examines phytochromes, the visual pigments in plants, highlighting their chromophore structures and the dynamics of photoconversion. The latter sections delve into chlorophylls, analyzing their optical spectra within photosynthetic reaction centers and the circular dichroism of chlorophylls in protein complexes. The work concludes with critical assessments of structural requirements for various chlorophyll forms and their implications for photosynthesis. This text serves as a valuable resource for researchers in biochemistry, photochemistry, and related fields, providing insights into the intricate relationships between structure, function, and optical properties of these essential biological pigments.