Frederic Lawrence Holmes Bücher

This is the first volume of a comprehensive scientific biography of Hans Krebs, one of the world's foremost biochemists. It treats his childhood, his medical education and scientific apprenticeship under Otto Warburg, his emergence as an independent investigator, and his discovery of the urea cycle in 1932. This early achievement, and his discovery of the citric acid cycle, are viewed as foundations for the modern structure of intermediary metabolism. During the writing of this fascinating history, the author had access to a complete set of Krebs' laboratory notebooks that reveal the daily dimensions of scientific creativity. Based in addition on many personal interviews with its subject, the Krebs biography is certain to interest and intrigue biochemists and historians of science alike. Volume 2: Hans Architect of Intermediary Metabolism 1933-37, will appear in spring, 1993.

This comprehensive volume completes Frederic Holmes' notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs' research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs' formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs, from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known--the formulation of the citric acid cycle. Holmes portrays Krebs' activity at the intimatelevel of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmes' fascinating portrait of Krebs integrates the great scientist's investigative pathways with his personal life. The result is an illuminating analysis of both man and scientist that will be of interest to biochemists and historians of science.

The book explores the contributions of Claude Bernard to the field of animal chemistry, highlighting his pioneering research and methodologies. It delves into his experiments and theories that laid the groundwork for modern physiology and biochemistry, showcasing the significance of his work in understanding the chemical processes within living organisms. Through an examination of Bernard's innovative approaches, the text emphasizes the impact of his findings on both science and medicine.

Antoine Lavoisier's groundbreaking work in quantitative experimental methods laid the foundation for modern science, emphasizing the conservation of mass. Frederic Holmes explores the formative year of 1773, when Lavoisier began his research on gases, revealing how he developed his innovative approach. Utilizing Lavoisier's laboratory notebooks, Holmes crafts a compelling narrative of a young scientist navigating the complexities of his discoveries, ultimately positioning him as a pivotal figure in the scientific revolution.

Through his development of quantitative experimental methods, the chemist Antoine Lavoisier (1743-1794) implemented a principle that many regard as the cornerstone of modern science: in every operation there is an equal quantity of material before and after the operation. The origin of Lavoisier's methods, however, has remained a missing piece in t