MHC molecules and antigen processing

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This book is about the basic functions of MHC molecules that provide the foundation for antigen recognition by T lymphocytes. In particular, the focus is on the cell biology and biochemistry of antigen processing mechanisms, which convert protein antigens to complexes of antigenic peptides and MHC molecules, which are required for stimulation of T lymphocytes. The major pathways of antigen processing are reviewed, and other alternate antigen processing mechanisms that contribute under certain circumstances are also examined. Exciting recent discoveries and future problems are discussed.