MicroRNA interference technologies

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MicroRNAs (miRNAs), approximately 22-nucleotide long endogenous noncoding regulatory mRNAs, have become crucial regulators of gene expression across various species, significantly influencing fundamental biological processes and the pathogenesis of human diseases. The advancements in miRNA research have sparked interest in their potential for therapeutic applications. Despite their promise, strategies for effectively utilizing miRNAs in treatment remain unclear. Recent years have seen the emergence of innovative methodologies related to miRNA research, demonstrating their efficacy in manipulating miRNA expression, biogenesis, and function. These advancements provide valuable tools for understanding miRNA roles and developing new therapeutic agents targeting them. The book offers a comprehensive overview of these technologies and their applications in miRNA research and drug design for miRNA-related diseases. It begins with a summary of current knowledge on miRNA biology and their therapeutic potential, followed by an introduction to the concept of miRNA interference (miRNAi) and its prospects. Subsequent chapters detail various miRNAi technologies, including their design, procedures, principles, and applications in basic research, R&D, and clinical therapy, showcasing the state-of-the-art developments in the field.