Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B

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The thesis focuses on the total synthesis of all stereoisomers of plakortide E, establishing the absolute configuration of the natural compound. It introduces a biomimetic approach for transforming Plakortide E methyl ester into plakortone B, showcasing innovative methods in organic synthesis and contributing to the understanding of these complex molecules.