Depression and Suicide

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Focusing on the genetics of major depressive disorder (MDD), this book explores the complexities of its polygenic nature and the challenges in studying its hereditary aspects. With a lifetime incidence of 10-15%, and a higher prevalence in women, understanding the disorder is crucial for developing effective treatments. The text emphasizes the need for genome-wide association studies and next-generation sequencing to identify genomic variants and dysregulated genes, aiming to unravel the intricate genetic architecture underlying MDD.