Endolysosomal Cation Channels of the Transient Receptor Potential Superfamily

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The dissertation explores the critical role of lysosomes in various diseases, including endolysosomal storage disorders and neurodegenerative conditions like Alzheimer's and Parkinson's. It emphasizes the importance of regulating fusion and fission processes, as well as ionic concentrations within the endolysosomal system. The study focuses on TRPML and TPC channels, detailing their physiological functions and the molecular mechanisms behind diseases linked to their dysfunction. Additionally, it discusses potential therapeutic strategies targeting these channels to mitigate associated pathologies.