Thiolated Cyclodextrin: The invisible drug delivery systems

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The book explores innovative strategies to enhance local drug delivery through mucosal tissues by utilizing cyclodextrins (CDs) modified for improved mucoadhesion and drug residence time. It details the thiolation process, which involves inducing aldehyde groups and conjugating with cysteamine to create non-ionic thiolated CDs. These modifications aim to increase water solubility and reduce irritation. The study highlights the advantages of thiomers, which form disulfide bonds with mucus glycoproteins, thereby extending the effectiveness of drug delivery systems.