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Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.
Buchkauf
Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Sprache
- Erscheinungsdatum
- 2014
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- (Paperback)
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- Untertitel
- Synthesis and Biological Evaluation
- Sprache
- Englisch
- Autor*innen
- Colm Duffy
- Verlag
- Springer, Berlin
- Erscheinungsdatum
- 2014
- Einband
- Paperback
- Seitenzahl
- 152
- ISBN13
- 9783642438929
- Reihe
- Springer Theses
- Schlagwörter
- Sachbücher
- Beschreibung
- Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.