Medical Humanities of Myxoedema in Africa

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The book delves into the evolving role of TRH testing in the context of advanced TSH assay methods, highlighting its limited necessity in most cases. It examines the significance of ultrasensitive tests alongside TRH, noting gaps in current evaluations. The authors investigate the strong correlation between T4 and TSH due to active deiodase enzymes in thyroid cells and explore genetic variability in enzyme activity. A study focuses on patients with treated peripheral hypothyroidism, analyzing TSH responses and determining optimal levothyroxine dosages for effective hormone replacement therapy.